miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway
Yuntian Hong, Xianghai Ren, Weicheng Liu, Kongliang Sun, Baoxiang Chen, Bo Liu, Xueqiao Yu, Quanjiao Chen, Qun Qian, Xiaoyu Xie, Congqing Jiang
Abstract
In this study, we constructed a murine model and identified a novel signaling mechanism involved in the chronic constipation progression. Our findings on the role of miR-128/p38α/M-CSF axis provide new insights into the treatment of chronic constipation.
Topics & Concepts
PathogenesisDownregulation and upregulationmicroRNASignal transductionInflammationCytokinep38 mitogen-activated protein kinasesImmunologyImmune systemCancer researchMedicineBiologyCell biologyMAPK/ERK pathwayGeneBiochemistryCongenital gastrointestinal and neural anomaliesGastrointestinal motility and disordersInflammatory Bowel Disease