A Cleavable C<sub>2</sub>-Symmetric <i>trans</i>-Cyclooctene Enables Fast and Complete Bioorthogonal Disassembly of Molecular Probes
Martin Wilkovitsch, Maximilian Haider, Barbara Sohr, Barbara Herrmann, Jenna Klubnick, Ralph Weissleder, Jonathan Carlson, Hannes Mikula
Abstract
TCO into fluorescent molecular probes, we demonstrate highly efficient extracellular and intracellular bioorthogonal disassembly via omnidirectional tetrazine-triggered cleavage.
Topics & Concepts
ChemistryBioorthogonal chemistryCycloocteneCombinatorial chemistryNanotechnologyOrganic chemistryCatalysisClick chemistryMaterials scienceClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthetic Organic Chemistry Methods