Design, synthesis and evaluation of cholinesterase hybrid inhibitors using a natural steroidal alkaloid as precursor
José L. Borioni, Valéria Cavallaro, Ana Paula Murray, Alicia B. Peñéñory, Marcelo Puiatti, Manuela E. García
Topics & Concepts
ButyrylcholinesteraseChemistryAcetylcholinesteraseCholinesteraseTacrineAlkaloidEnzymeContext (archaeology)Docking (animal)Active sitePharmacologyBiochemistryStereochemistryAchéBiologyMedicinePaleontologyNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsChemical synthesis and alkaloids