Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Bas Ponsioen, Jasmin B. Post, Julian R. Buissant des Amorie, Dimitrios Laskaris, Ravian L. van Ineveld, Simone Kersten, Andrea Bertotti, Francesco Sassi, François Sipieter, Benjamin Cappe, Sander Mertens, Ingrid Verlaan-Klink, Sylvia F. Boj, Rob G. J. Vries, Holger Rehmann, Peter Vandenabeele, Franck B. Riquet, Livio Trusolino, Johannes L. Bos, Hugo J.G. Snippert
Topics & Concepts
MAPK/ERK pathwayKRASCancer researchCell biologySignal transductionEpidermal growth factor receptorKinaseBiologyOrganoidChemistryColorectal cancerCancerGeneticsMelanoma and MAPK PathwaysCancer Cells and MetastasisCellular Mechanics and Interactions