Prospective Cohort Study of Micafungin Population Pharmacokinetic Analysis in Plasma and Peritoneal Fluid in Septic Patients with Intra-abdominal Infections
Nicolas Garbez, Litaty Mbatchi, Steven C. Wallis, Laurent Müller, Jeffrey Lipman, Jason A. Roberts, Jean‐Yves Lefrant, Claire Roger
Abstract
The objective of this study was to describe the pharmacokinetics (PK) of micafungin in plasma and peritoneal fluid in septic patients with intra-abdominal infections. Twelve patients with secondary peritonitis in septic shock receiving 100 mg micafungin once daily were included.
Topics & Concepts
MicafunginPharmacokineticsMedicineSeptic shockPopulationDosingPeritoneal fluidGastroenterologyInternal medicineFluconazoleSepsisAntifungalEnvironmental healthDermatologyAntifungal resistance and susceptibilityHelminth infection and controlAntibiotics Pharmacokinetics and Efficacy