Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways
Wenjuan Chen, Mengning Sun, Yi Sun, Qinglan Yang, Hui Gao, Li Li, Rongrong Fu, Na Dong
Topics & Concepts
BortezomibProteasome inhibitorApoptosisProteasomeUnfolded protein responseProgrammed cell deathXIAPMG132Intrinsic apoptosisCaspase 8Cancer researchChemistryCaspase 3CaspaseCell biologyBiologyMultiple myelomaImmunologyBiochemistryUbiquitin and proteasome pathwaysCell death mechanisms and regulationEndoplasmic Reticulum Stress and Disease