Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases
Yuxiang Wang, Zhao‐hua Deng, Yuyan Li, Ke Bai, Jinjin Ma, Yang Liu, Qi Chen
Abstract
Hematopoiesis and the behavior of hematopoietic stem and progenitor cells (HSPCs) are regulated by the bone marrow niche. Here, we introduce the major niche cell types in bone marrow and their response to stress condition. We highlight the hematopoietic response and bone marrow niche adaptation to inflammatory condition and non-hematopoietic diseases, which are not systematically summarized. These emerging data suggest targeting hematopoiesis and bone marrow niche may provide novel therapeutic target to precisely control the progression of the diseases.
Topics & Concepts
HaematopoiesisBone marrowNicheProgenitor cellBiologyHematopoietic stem cellImmunologyStem cellCell biologyEcologyHematopoietic Stem Cell TransplantationImmune cells in cancerChemokine receptors and signaling