Photocatalytic synthesis of azaheterocycle-fused piperidines and pyrrolidines<i>via</i>tandem difunctionalization of unactivated alkenes
Qun-Huai Zhou, Jia‐Ying Dai, Wenjing Zhao, Xi-Ya Zhong, Chunyang Liu, Weiwei Luo, Zhiwei Li, Jiang‐Sheng Li, Weidong Liu
Abstract
tandem tri- and difluoromethylation-arylation of pendent unactivated alkenes. Benzimidazole, imidazole, theophylline, purine, and indole serve as applicable anchors, thereby enriching the structural diversity of piperidine and pyrrolidine derivatives. This method features mild, additive-free and transition metal-free conditions.
Topics & Concepts
PyrrolidineChemistryImidazolePiperidineCombinatorial chemistryPhotocatalysisBenzimidazoleTandemIndole testCascade reactionOrganic chemistryCatalysisComposite materialMaterials scienceRadical Photochemical ReactionsFluorine in Organic ChemistrySulfur-Based Synthesis Techniques