Untargeted Gut Metabolomics to Delve the Interplay between Selenium Supplementation and Gut Microbiota
Belén Callejón‐Leblic, Marta Selma‐Royo, María Carmen Collado, José Luis Gómez‐Ariza, Nieves Abril, Tamara García‐Barrera
Abstract
, a potentially beneficial genus enriched after Se-supplementation, was associated with higher levels of prenol lipids, phosphatidylglycerols (C-Se), steroids and diterpenoids (Abx-Se), and also with lower levels of fatty acids (Abx-Se). Thus, we observed a crucial interaction between Se intake-microbiota-metabolites, although further studies to clarify the specific mechanisms are needed. This is the first study about untargeted gut metabolomics after microbiota depletion and Se-supplementation.
Topics & Concepts
Gut floraMetabolomicsSeleniumBiologyGut bacteriaGut microbiomeComputational biologyBioinformaticsChemistryBiochemistryOrganic chemistryGut microbiota and healthNutritional Studies and DietDietary Effects on Health