Application of Design of Experiments® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
Syed Nazrin Ruhina Rahman, Oly Katari, Datta Maroti Pawde, Gopi Sumanth Bhaskar Boddeda, Abhinab Goswami, Srinivasa Rao Mutheneni, Tamilvanan Shunmugaperumal
Topics & Concepts
Quality by DesignRepeatabilityCritical quality attributesRobustness (evolution)High-performance liquid chromatographyChromatographyMean squared errorCorrelation coefficientDesign of experimentsCentral composite designFactorial experimentLinearityBiological systemChemistryMathematicsComputer scienceResponse surface methodologyMachine learningStatisticsEngineeringParticle sizeElectrical engineeringPhysical chemistryGeneBiochemistryBiologyAnalytical Methods in PharmaceuticalsAnalytical Chemistry and ChromatographyAdvanced Drug Delivery Systems