Molecular packing of pharmaceuticals analyzed with paramagnetic relaxation enhancement and ultrafast magic angle pinning NMR
Xingyu Lu, Yu Tsutsumi, Chengbin Huang, Wei Xu, Stephen R. Byrn, Allen C. Templeton, Alexei V. Buevich, Jean‐Paul Amoureux, Yongchao Su
Abstract
F networks for identifying "head-to-tail" and "head-to-head" intermolecular packings, with presumably critical contacts that stabilize the crystalline structure. The PRE and UF-MAS techniques enable the high-resolution structure characterization of fluorinated drug molecules in pharmaceutical formulations at natural abundance.
Topics & Concepts
Relaxation (psychology)ParamagnetismMaterials scienceMagic angleNuclear magnetic resonanceTwo-dimensional nuclear magnetic resonance spectroscopyCondensed matter physicsNuclear magnetic resonance spectroscopyChemical physicsChemistryCrystallographyPhysicsMedicineInternal medicineAdvanced NMR Techniques and ApplicationsNMR spectroscopy and applicationsAdvanced MRI Techniques and Applications