Transfer of lncRNA UCA1 by hUCMSCs-derived exosomes protects against hypoxia/reoxygenation injury through impairing miR-143-targeted degradation of Bcl-2
Liwei Diao, Qinghua Zhang
Abstract
experiments showed that hUCMSC-ex protected I/R rats and H/R CMECs against injury. Silencing UCA1 in hUCMSC-ex or miR-143 overexpression aggravated H/R injury in CMECs. LncRNA UCA1 competitively bound to miR-143 to upregulate Bcl-2. And hUCMSCs-ex/si-UCA1+inhi-miR-143 treatment protected CMECs against H/R injury and inhibited hyperautophagy. Together, hUCMSC-ex-derived lncRNA UCA1 alleviates H/R injury through the miR-143/Bcl-2/Beclin-1 axis. Hence, this study highlights a stem cell-based approach against I/R injury.
Topics & Concepts
MicrovesiclesHypoxia (environmental)microRNADegradation (telecommunications)Cell biologyCancer researchExosomeChemistryMedicineBiologyBiochemistryComputer scienceOxygenGeneOrganic chemistryTelecommunicationsFuel Cells and Related MaterialsCardiac Ischemia and ReperfusionCancer-related molecular mechanisms research