The Bioavailability Prediction and Screening Phytochemicals of Sansevieria Trifasciata Leaves Extract
Nur Oomariyah, Gertian van Dijk
Abstract
Leaves and rhizomes of Sansevieria trifasciata are used to treat some infectious diseases and have anti-diabetes potential. Active compounds and their bioavailability are not known yet. This study aimed to identify phytochemical compounds of Sansevieria trifasciata leaves and their orally bioavailability by absorption, distribution, metabolism, and excretion (ADME) evaluation. Leaves were obtained from the Tropical Biopharmaca Research Center, IPB University. After drying in an oven (38±2°C) for seven days and pulverized, the powder leaves macerated in 5 ml 100% methanol/g. After five days, extracts were filtered and evaporated using the rotary evaporator system. A bioactive test was carried out by mixing extracts with a reagent to screen alkaloids, flavonoids, saponin, steroids, triterpenoids, tannins, and phenolic compounds. Samples were injected into GC-MS using column (HP5), fused silica tubing 30 m long (0.25 mm I.D) filled with acetonitrile. Sansevieria trifasciata bioactive was analyzed using the Swiss-ADME tool to check their bioavailability. The qualitative screening showed the presence of main plant compounds. The GC-MS analysis presented phytol, stigmasterol, linoleic acid, oleic acid, stearic acid, and palmitic acid. The SwissADME showed bioavailability phytochemicals of Sansevieria trifasciata not orally available according to Lipinski’s rules using SwissADME. It indicated that extract of Sansevieria trifasciata has promising potential as an alternative medicine compound.