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Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition

Abdul Sadiq, Mater H. Mahnashi, Bandar A. Alyami, Yahya S. Alqahtani, Ali O. Alqarni, Umer Rashid

2021Bioorganic Chemistry50 citationsDOI

Topics & Concepts

ChemistryActive siteCarbonic anhydraseEnzymeArachidonate 5-lipoxygenaseDocking (animal)Structure–activity relationshipPyrrolidineBiochemistryIC50StereochemistryIn vitroArachidonic acidNursingMedicineInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis and Biological Evaluation
Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition | Litcius