Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways
Liemei Guo, Jing Cui, Herui Wang, Rogelio Medina, Shilei Zhang, Xiaohua Zhang, Zhengping Zhuang, Yingying Lin
Abstract
, an effect mediated through the activation of AMPK and repression of mTOR signaling pathways. Our study suggests the combined treatment of metformin and cisplatin is an effective and safe treatment for high-grade meningiomas.
Topics & Concepts
AMPKMetforminPI3K/AKT/mTOR pathwayCisplatinCancer researchSignal transductionMedicineChemistryInternal medicineDiabetes mellitusEndocrinologyPhosphorylationProtein kinase AChemotherapyBiochemistryMetabolism, Diabetes, and CancerHedgehog Signaling Pathway StudiesMechanisms of cancer metastasis