Comparative metabolomics in the Pahenu2 classical PKU mouse identifies cerebral energy pathway disruption and oxidative stress
Steven F. Dobrowolski, Yu Leng Phua, Cayla Sudano, Kayla Spridik, Pascal O. Zinn, Yu Wang, Sivakama S. Bharathi, Jerry Vockley, Eric S. Goetzman
Topics & Concepts
HyperphenylalaninemiaOxidative stressMitochondrial respiratory chainRespiratory chainOxidative phosphorylationEndocrinologyInternal medicineMetabolomeNeuropathologyPhenylalanine hydroxylaseMitochondrionPhenylalanineChemistryBiochemistryBiologyMedicineMetaboliteAmino acidDiseaseMetabolism and Genetic DisordersMetabolomics and Mass Spectrometry StudiesDiet and metabolism studies