Vertical transmission of SARS CoV-2: a systematic review

Melis Deniz, Hasan Tezer

2020The Journal of Maternal-Fetal & Neonatal Medicine63 citationsDOI Open Access PDF

Abstract

OBJECTIVE: The aim of this study is to review the current evidence on the vertical transmission of SARS CoV-2. METHODS: Combination of the following keywords; COVID-19, SARS CoV-2, placenta, vertical transmission, intrauterine infection, breast milk were searched in databases. RESULTS: In the 50 studies included, 17 newborns testing positive for SARS CoV-2 by RT-PCR were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated. Eight placental tissues testing positive for the virus were reported. Three positive RT-PCR results of test of breast milk have been reported recently. One amniotic fluid testing positive was reported. CONCLUSION: Possible vertical transmission of SARS CoV-2 has been observed in some studies currently. More RT-PCR tests on amniotic fluid, placenta, breast milk and cord blood are required.

Topics & Concepts

Amniotic fluidBreast milkPlacentaMedicineTransmission (telecommunications)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)ObstetricsUmbilical cordPregnancyVirologyImmunologyInternal medicineBiologyDiseaseFetusInfectious disease (medical specialty)BiochemistryEngineeringElectrical engineeringGeneticsCOVID-19 Impact on ReproductionSARS-CoV-2 detection and testingCOVID-19 Clinical Research Studies