Erythroid-transdifferentiated myeloid cells promote portal vein tumor thrombus in hepatocellular carcinoma
Wei-Hang Zhu, Jie Chen, Runkai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu‐Qing Pang, Bo Hu, Yang Yang, Xing Li
Abstract
EPCs enriched in the HCC microenvironment are EDMCs, which are induced by HCC macrophages to migrate from the circulation to the TME. Subsequently, EDMCs promote PVTT by compromising the blood vessel endothelium, aggravating coagulation, and promoting HCC cell migration.
Topics & Concepts
Progenitor cellCancer researchMyeloidHepatocellular carcinomaAngiogenesisMedicineBiologyStem cellCell biologyImmune cells in cancerPancreatic and Hepatic Oncology ResearchFibroblast Growth Factor Research