Inherent Capability of Self‐Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis (Small 9/2023)
Qian‐Wei Luo, Yao Lü, Ling Li, Zhuo Yang, Mei‐Mei Zhao, Yong‐Zhe Zheng, Fang‐Fang Zhuo, Tingting Liu, Xiaowen Zhang, Dan Liu, Peng‐Fei Tu, Ke‐Wu Zeng
Abstract
Cancer Cell Pyroptosis In article number 2205531, Ke-Wu Zeng and co-workers describe the natural product oleanolic acid-based self-assembling nanostructures specially bind to proteasome subunit alpha 6 (PSMA6) to activate proteasome for cancer cell pyroptosis. This study opens up a new direction for the development anti-cancer nanomedicine from natural resources.
Topics & Concepts
PyroptosisProteasomeNanomedicineNanotechnologyCancerCancer cellCellMaterials scienceCell biologyCancer researchChemistryProgrammed cell deathBiochemistryApoptosisBiologyMedicineNanoparticleInternal medicinePeptidase Inhibition and AnalysisAdvanced Nanomaterials in CatalysisUbiquitin and proteasome pathways