Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis
Ning Li, Леи Жао, Xinyu Geng, Jingyang Liu, Xu Zhang, Ying Hu, Jihan Qi, Hongliang Chen, Jiawei Qiu, Xiaoyu Zhang, Shizhu Jin
Abstract
This study revealed a vital role for Hy-Exos in suppressing inflammatory progression in UC and suggested that miR-214-3p is a potential critical target for Hy-Exos in alleviating UC.
Topics & Concepts
MitophagyPI3K/AKT/mTOR pathwayMicrovesiclesMesenchymal stem cellProtein kinase BCell biologyCancer researchChemistryUlcerative colitisExosomeSignal transductionApoptosisAutophagyMedicineBiologyPathologymicroRNABiochemistryGeneDiseaseExtracellular vesicles in diseaseMicroRNA in disease regulationCancer-related molecular mechanisms research