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Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, Amanda Swain, Tyler Levy, Kelly R. Miller, Pietro Luigi Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K. Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A. Bennett, Julie A. Schneider, Michael R. Nichols, Sean A. Beausoleil, Jason D. Ulrich, David M. Holtzman, Maxim N. Artyomov, Marco Colonna

2020Nature Medicine1,208 citationsDOIOpen Access PDF

Topics & Concepts

TREM2DiseaseTranscriptomeNeuroscienceAlzheimer's diseaseBiologyNucleusMicrogliaMedicineGeneGeneticsImmunologyPathologyGene expressionInflammationNeuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysMedicinal Plants and Neuroprotection
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease | Litcius