Genomic gain of <i>RRS1</i> promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling
Pengbo Cao, Aiqing Yang, Peiyao Li, Xia Xia, Yuqing Han, Guangming Zhou, Rui Wang, Fei Yang, Yuanfeng Li, Ying Zhang, Ying Cui, Hongzan Ji, Lei Lü, Fuchu He, Gangqiao Zhou
Abstract
Our findings established that the chromosome 8q oncogene RRS1 promotes HCC development through attenuating the RPL11-MDM2-p53 pathway and provided new potential targets for treatment of this malignancy.
Topics & Concepts
Ribosome biogenesisMdm2Somatic cellHCCSBiologyTranscriptomeCancer researchBiogenesisHepatocellular carcinomaOncogeneGeneticsGeneRibosomeGene expressionCell cycleRNARNA modifications and cancerCancer-related Molecular PathwaysCancer Genomics and Diagnostics