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The potential role of Tirzepatide as adjuvant therapy in countering colistin-induced nephro and neurotoxicity in rats via modulation of PI3K/p-Akt/GSK3-β/NF-kB p65 hub, shielding against oxidative and endoplasmic reticulum stress, and activation of p-CREB/BDNF/TrkB cascade

Noha F. Hassan, Diaa Ragab, Shaimaa G. Ibrahim, Mona Mohamed Abd Elgalil, Asmaa Hassan Abd-El-Hamid, Dalia Hamed, Mira Magdy William, Maha A. Salem

2024International Immunopharmacology22 citationsDOI

Topics & Concepts

NeurotoxicityPI3K/AKT/mTOR pathwayAdjuvantProtein kinase BOxidative phosphorylationColistinMedicineOxidative stressChemistryCancer researchPharmacologyImmunologyPhosphorylationToxicitySignal transductionBiochemistryInternal medicineAntibioticsNeonatal Health and BiochemistryBiomedical Research and PathophysiologyPediatric Hepatobiliary Diseases and Treatments
The potential role of Tirzepatide as adjuvant therapy in countering colistin-induced nephro and neurotoxicity in rats via modulation of PI3K/p-Akt/GSK3-β/NF-kB p65 hub, shielding against oxidative and endoplasmic reticulum stress, and activation of p-CREB/BDNF/TrkB cascade | Litcius