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Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines

Belgin Sever, Mehlika Dilek Altıntop, Yeliz Demir, Nalan Yılmaz, Gülşen Akalın Çiftçi, Şükrü Beydemir, Ahmet Özdemır

2021Chemico-Biological Interactions72 citationsDOI

Topics & Concepts

Aldose reductaseIC50ChemistryAldose reductase inhibitorIn silicoCytotoxicityMoietyPharmacologyBioavailabilityIn vitroDocking (animal)StereochemistrySorbinilPyrazolineBiochemistryEnzymeMedicineMedicinal chemistryGeneNursingAldose Reductase and TaurineEnzyme function and inhibitionSynthesis and Characterization of Pyrroles
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines | Litcius