Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein
Adeniyi T. Adewumi, Opeyemi Soremekun, Mary B. Ajadi, Mahmoud E. S. Soliman
Abstract
Graphical superimposed snapshots of the Thompson novel loop (yellow) of<italic>menG</italic>protein: apo (A) and bound (B) systems. The loop switches between open and closed conformations; critical for therapeutic activity.
Topics & Concepts
AmideChemistryProtein structureComputational biologyStereochemistryBiochemistryBiophysicsBiologyVitamin K Research StudiesComputational Drug Discovery MethodsEnzyme Structure and Function