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Design, synthesis and biological evaluation of new dihydropyridine derivatives as PD-L1 degraders for enhancing antitumor immunity

Chenghao Pan, Mengxin Luo, Yang Lu, Xiaohui Pan, Xi Chen, Ling Ding, Jinxin Che, Qiaojun He, Xiaowu Dong

2022Bioorganic Chemistry14 citationsDOI

Topics & Concepts

ChemistryImmunotherapyPD-L1BlockadeSmall moleculeImmune checkpointImmune systemCancer researchT cellCell biologyPharmacologyReceptorBiochemistryImmunologyBiologyCancer therapeutics and mechanismsCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction
Design, synthesis and biological evaluation of new dihydropyridine derivatives as PD-L1 degraders for enhancing antitumor immunity | Litcius