Tsp-1<sup>+</sup> microglia attenuate retinal neovascularization by maintaining the expression of Smad3 in endothelial cells through exosomes with decreased miR-27a-5p
Qian Luo, Zi‐Hua Jiang, Jingyi Jiang, Linxi Wan, Yan Li, Yuke Huang, Jin Qiu, Keming Yu, Jing Zhuang
Abstract
Collectively, the Tsp-1/miR-27a-5p/Smad3 axis is involved in microglia-related and exosome-mediated antiangiogenic regulation of the retina. Therefore, this study reveals a novel mechanism by which retinal microglia maintain vascular homeostasis, thereby providing a new therapeutic target for pathological neovascularization.
Topics & Concepts
MicrogliaAngiogenesisCell biologyMicrovesiclesRetinalBiologyNeovascularizationRetinaImmunologyChemistrymicroRNACancer researchNeuroscienceInflammationGeneticsBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsRetinal Diseases and TreatmentsInflammation biomarkers and pathways