A <i>de novo</i> strategy for the development of a Zn<sup>II</sup>–organic framework based luminescent “switch-on” assay for size-exclusive sensitization of the oxidised form of glutathione (GSSG) over the reduced form (GSH): insights into the sensing mechanism through DFT
Sourav Bej, Riyanka Das, Debojyoti Kundu, Tapan K. Pal, Priyabrata Banerjee
Abstract
The ratio of GSSG to GSH plays a key role as a biomarker for monitoring cellular health thus fuelling extensive ground-breaking research towards the development of robust sensory receptors for continuous monitoring of glutathione concentration.
Topics & Concepts
GlutathioneSensitizationChemistryBiomarkerLuminescenceCombinatorial chemistryBiophysicsBiochemistryBiologyMaterials scienceImmunologyOptoelectronicsEnzymeMetal-Organic Frameworks: Synthesis and ApplicationsSulfur Compounds in BiologyMolecular Sensors and Ion Detection