The development of two fluorescent chemosensors for the selective detection of Zn<sup>2+</sup> and Al<sup>3+</sup> ions in a quinoline platform by tuning the substituents in the receptor part: elucidation of the structures of the metal-bound chemosensors and biological studies
Pravat Ghorai, Kunal Pal, Parimal Karmakar, Amrita Saha
Abstract
ions in the triple negative human breast cancer cell line MDA-MB-468 was evaluated with the aid of fluorescence imaging. Mechanistic insights into the anticancer activity of complexes 1 and 2 were also demonstrated in this study. To the best of our knowledge, this is the first time that this type of biological and sensing activity for 8-aminoquinoline-based complexes has been demonstrated in a single platform.
Topics & Concepts
QuinolineFluorescenceIonChemistryCombinatorial chemistryOrganic chemistryPhysicsQuantum mechanicsMolecular Sensors and Ion DetectionElectrochemical Analysis and ApplicationsAdvanced biosensing and bioanalysis techniques