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A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

Jonathan M. Ghergurovich, Juan Carlos García‐Cañaveras, Joshua Z. Wang, Emily N. Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, Mari Carmen Gómez‐Cabrera, Agustín Lahoz, Jing Fan, Ulf H. Beier, Hahn Kim, Joshua D. Rabinowitz

2020Nature Chemical Biology208 citationsDOIOpen Access PDF

Topics & Concepts

Pentose phosphate pathwayGlucose-6-phosphate dehydrogenaseNicotinamide adenine dinucleotide phosphateBiochemistryDehydrogenaseOxidative phosphorylationRespiratory burstGlycolysisChemistryNAD+ kinaseMetaboliteBiologyEnzymeCell biologyOxidase testNeonatal Health and BiochemistryNitric Oxide and Endothelin EffectsHeme Oxygenase-1 and Carbon Monoxide
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway | Litcius