Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023
Catarina Gouveia, Maria Paula Bajanca-Lavado, Rafael Mamede, Ana Araújo Carvalho, Fernanda Rodrigues, José Melo‐Cristino, Mário Ramirez, Ana Friães, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Pediatric Invasive Streptococcal Disease
Abstract
Since autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1 UK sublineage (26/55) and more diverse emm 12 isolates (12/55).