Disrupting the ArcA Regulatory Network Amplifies the Fitness Cost of Tetracycline Resistance in Escherichia coli
Mario L. Arrieta‐Ortiz, Min Pan, Amardeep Kaur, Evan Pepper-Tunick, Vivek Srinivas, Ananya Dash, Selva Rupa Christinal Immanuel, Aaron N. Brooks, Tyson R. Shepherd, Nitin S. Baliga
Abstract
E. coli to tetracycline. Thus, we describe a generalizable systems biology approach to identify new vulnerabilities within AMR strains to rationally accelerate the discovery of therapeutics that extend the life span of existing antibiotics.
Topics & Concepts
TetracyclineEscherichia coliAntibiotic resistanceAntimicrobialResistance (ecology)BiologyMicrobiologyAntibioticsEcologyGeneticsGeneAntibiotic Resistance in BacteriaEvolution and Genetic DynamicsPharmaceutical and Antibiotic Environmental Impacts