Assessment B-cell-activating factor (BAFF) in thrombocytopenia patients
Noor Alhuda Ghanem Al-Fatlawi, Arshad Noori Al-Dujaili, Talib Hussein Nooruldeen Kammona
Abstract
Thrombocytopenia is a reduction in circulating platelet levels. Primary thrombocytopenia or idiopathic or immune thrombocytopenia purpura (ITP) is an autoimmune disorder of unknown cause affecting both children and adults and thrombocytopenia that a result from a known condition is called secondary thrombocytopenia. The B-Cell-Activating Factor (BAFF) belonging to the tumor necrosis factor (TNF) superfamily are key actors for the B-cell survival then the immune responses concerning mature B-cells, BAFF and APRIL are concerned of the pathogenesis of a variety of human autoimmune diseases. To discover the pathophysiologic characteristic concerning BAFF within thrombocytopenia we investigated serum level of BAFF ITP and secondary thrombocytopenia. The study was applied on 85 people aged 20 to 69 year; 65 patients group with thrombocytopenia and 30 healthy group as a control group. The group of patients was divided into subgroups based on gender, age, body mass index (BMI), primary and secondary thrombocytopenia. The complete blood count were examined for all patients group and healthy group. BAFF serum level was significantly decrease (P<0.05) in thrombocytopenia patients than controls. Primary thrombocytopenia show non-significant decrease (P>0.05) in BAFF serum compare with secondary thrombocytopenia. The results exhibited non a significant increase (P>0.05) in serum BAFF level in female compared with male thrombocytopenia patients and indicated non-significant differences (P>0.05) in serum BAFF level of patients at different ages group and different types of body mass index (normal weight, over weight and obese weight) respectively. The results of correlation and linear regression indicated a significant negative (P<0.05) correlation between BAFF and platelets and significant positive(P<0.05) correlation between BAFF and leucocytes counts in primary thrombocytopenia, while significant positive(P<0.05) correlation between BAFF and platelets concentrations and non-significant positive (P>0.05) correlation BAFF and leucocytes counts in secondary thrombocytopenia. Current study was aimed to determine BAFF which can be used for diagnosis and prognosis of ITP.