Targeting the integrated stress response in ophthalmology
Hsiao-Sang Chu, Cornelia Peterson, Albert S. Jun, James W. Foster
Abstract
The eye is uniquely exposed to ISR responsive stressors due to its environmental exposure and relative isolation from the circulatory system which are necessary for its function. We will discuss how this pathway is critical for the proper function of the tissue, its role in development, as well as how targeting of the pathway could alleviate key aspects of diverse ophthalmic diseases.
Topics & Concepts
Integrated stress responseSignal transductionCell biologyBiologyContext (archaeology)ExtracellularPhenotypeTranslation (biology)ImmunologyGeneticsMessenger RNAPaleontologyGeneEndoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseRedox biology and oxidative stress