Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
Tzu‐Yu Chen, Jinfeng Chen, Yijie Tang, Jiahai Zhou, Yisong Guo, Wei‐chen Chang
Abstract
Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.
Topics & Concepts
ChemistryMechanism (biology)Group (periodic table)BiosynthesisCombinatorial chemistryBiochemistryOrganic chemistryEpistemologyGenePhilosophySynthesis and Catalytic ReactionsChemical Synthesis and AnalysisMicrobial Natural Products and Biosynthesis