Synthesis and in vivo evaluation of novel benzimidazole‐sulfonamide hybrids and <i>Lucilia cuprina</i> maggots' excretion/secretion topical gels for wound healing
Asmaa M Sayed, Nashwa M. Saleh, M. S. A. El‐Gaby, Mohammad Abdel-Samad, Fatma A. Taher
Abstract
Abstract A novel series of benzimidazole‐sulfonamide hybrids ( 6a – g ) was designed, synthesized, and their structures were characterized by 1 H NMR and 13 C NMR spectral data. Further, all compounds were evaluated for their antibacterial effects. The synthesized benzimidazole‐sulfonamide hybrid ( 6d ) showed the highest antibacterial activity against Staphylococcus aureus , Staphylococcus epidermis , Escherichia coli , and Klebsiella pneumonia . Different gel formulations for 6d were prepared and physically investigated. After in vivo evaluation for wound healing, the 6d gel formulation delayed the wound healing in animal model. But interestingly, a combination of 6d and Lucilia cuprina maggots' excretion/secretion showed remarkable enhancement in wound healing compared with 6d only. This combination opens up promising prospects for wound healing formulations.