Biomimetic Nanozyme-Decorated Hydrogels with H<sub>2</sub>O<sub>2</sub>-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound
Yüe Zhao, Yüe Zhao, Dongdong Wang, Tianwei Qian, Junmin Zhang, Zuhao Li, Qiaoyun Gong, Xiangzhong Ren, Yanli Zhao, Yanli Zhao
Abstract
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels are promising systems for DFU-based wound management, their effectiveness is often hindered by the immune response and hostile wound microenvironment associated with the uncontrollable accumulation of reactive oxygen species and hypoxia. Here, we develop a therapeutic wound dressing using a biomimetic hydrogel system with the decoration of catalase-mimic nanozyme, namely, MnCoO@PDA/CPH. The hydrogel can be designed to match the mechanical and electrical cues of skins simultaneously with H 2 O 2 -activated oxygenation ability. As a proof of concept, DFU-based rat models are created to validate the therapeutic efficacy of the MnCoO@PDA/CPH hydrogel in vivo. The results indicate that the developed hydrogel can promote DFU healing and improve the quality of the healed wound as featured by alleviated proinflammatory, increased re-epithelialization, highly ordered collagen deposition, and functional blood vessel growth.