Clinical Efficacy of Cefixime for the Treatment of Early Syphilis
Chrysovalantis Stafylis, Kori Keith, Shivani Mehta, David Tellalian, Pamela Burian, Carl Millner, Jeffrey D. Klausner
Abstract
Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%-100%; 13/15). Clinical Trials Registration. NCT03752112.
Topics & Concepts
CefiximeMedicineRapid plasma reaginSyphilisConfidence intervalClinical trialTiterRandomized controlled trialClinical efficacySurgeryInternal medicineImmunologyAntibioticsCeftriaxoneTreponemaMicrobiologyAntibodyHuman immunodeficiency virus (HIV)BiologySyphilis Diagnosis and TreatmentReproductive tract infections researchHIV/AIDS Research and Interventions