Design, synthesis and bioevaluation of 1,2,4-thiadiazolidine-3,5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer's disease
Yongxi Dong, Jun Lü, Shanhui Zhang, Lina Chen, Jinlan Wen, Fang Wang, Yongqing Mao, Lei Li, Jiquan Zhang, Shang‐Gao Liao, Dong Li
Topics & Concepts
ChemistryNeuroprotectionIn vivoPharmacologyKinaseGSK-3Progressive supranuclear palsyBiochemistryStereochemistryInternal medicineMedicineDiseaseBiotechnologyBiologyCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsPhosphodiesterase function and regulation