Copper-Catalyzed Direct Allenylation of Inactive Cyclic Ethers
Yichuan Zhao, Jinlin Wang, Zhe Zhang, Xuesong Li, Zhi‐Jie Niu, Xue‐Yuan Liu
Abstract
We report here a direct allenylation reaction of inactive cyclic ethers. The reaction proceeds through a copper-catalyzed 1,4-difunctionalization of 1,3-enynes, with cyano group installed at the allenes simultaneously. This methodology shows a broad functional group compatibility to 1,3-enynes. Diversified allene-modified cyclic ether derivatives were synthesized with high regioselectivity under mild conditions.
Topics & Concepts
AlleneRegioselectivityCatalysisChemistryCopperCompatibility (geochemistry)EtherFunctional groupCombinatorial chemistryOrganic chemistryEngineeringChemical engineeringPolymerCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions