Knocking down EGR1 inhibits nucleus pulposus cell senescence and mitochondrial damage through activation of PINK1-Parkin dependent mitophagy, thereby delaying intervertebral disc degeneration
Zuolong Wu, Ke-Ping Wang, Yajun Chen, Wei Song, Yong Liu, Kai‐Sheng Zhou, Peng Mao, Zhongjun Ma, Hai-Hong Zhang
Topics & Concepts
ParkinMitophagyPINK1Cell biologyMitochondrionNucleusDegeneration (medical)Intervertebral discChemistrySenescenceAutophagyBiologyAnatomyApoptosisMedicinePathologyBiochemistryDiseaseParkinson's diseaseSpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationSpinal Cord Injury Research