Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
Danya Zhang, Yuxin Chen, Yue Sun, Hanjie Xu, Rui Wei, Ying Zhou, Fei Li, Jie Li, Jing Wang, Pingbo Chen, Ling Xi, Ling Xi
Topics & Concepts
Gambogic acidApoptosisCell biologyChemistryCancer researchCaspase 8CaspaseCancer cellMitochondrionSignal transductionReactive oxygen speciesPoly ADP ribose polymeraseProgrammed cell deathBiologyCancerBiochemistryEnzymeGeneticsPolymeraseNatural Compound Pharmacology StudiesSphingolipid Metabolism and SignalingCarbohydrate Chemistry and Synthesis