Effect of <i>Lacticaseibacillus paracasei</i> strain Shirota supplementation on clinical responses and gut microbiome in Parkinson's disease
Xiaodong Yang, Xiaoqin He, Shaoqing Xu, Yi Zhang, Chengjun Mo, Yiqiu Lai, Yanyan Song, Yan Zheng, Penghui Ai, Yiwei Qian, Qin Xiao
Abstract
in the probiotic group compared with those at the baseline and in the placebo group. The faecal concentration of L-tyrosine was significantly decreased and the plasma concentration of L-tyrosine was increased in the probiotic group compared with the placebo group. Our study demonstrated that although supplementation with LcS did not induce major changes in the global gut microbiome, the probiotic had favorable effects in managing constipation and other non-motor symptoms in PD patients. This study was registered at the Chinese Clinical Trial Registry: ChiCTR1800016795.
Topics & Concepts
Gut floraProbioticPlaceboFecesConstipationLactobacillus paracaseiMedicineDiseaseInternal medicineGastroenterologyPhysiologyMicrobiomeGut microbiomeBiologyImmunologyBioinformaticsPathologyMicrobiologyBacteriaAlternative medicineGeneticsParkinson's Disease Mechanisms and TreatmentsDysphagia Assessment and ManagementGut microbiota and health