Cu/Pd-Catalyzed <i>cis-</i>Borylfluoroallylation of Alkynes for the Synthesis of Boryl-Substituted Monofluoroalkenes
Ayman M. Y. Suliman, Ebrahim‐Alkhalil M. A. Ahmed, Tian‐Jun Gong, Yao Fu
Abstract
Monofluoroalkenes normally act as metabolically stable bioisosteres for amide groups (−NH–CO−) and have widespread applications in drug discovery. Additionally, they are widely used as building blocks in organic synthesis. In this study, the Cu/Pd-catalyzed cis-borylfluoroallylation of alkynes was achieved, providing a modular and general tactic for the preparation of monofluorinated alkene scaffolds with high regioselectivity and stereoselectivity. Moreover, an array of synthetic building blocks can be generated by downstream transformations.
Topics & Concepts
ChemistryAlkeneRegioselectivityCatalysisStereoselectivityAmideCombinatorial chemistryModular designStereochemistryOrganic chemistryProgramming languageComputer scienceFluorine in Organic ChemistryOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods