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Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity

John P. Murad, Dileshni Tilakawardane, Anthony K. Park, Lupita S. Lopez, Cari A. Young, Jackson Gibson, Yukiko Yamaguchi, Hee Jun Lee, Kelly T. Kennewick, Brenna Gittins, Wen-Chung Chang, Chau P. Tran, Catalina Martínez, Anna M. Wu, Robert E. Reiter, Tanya B. Dorff, Stephen J. Forman, Saul J. Priceman

2021Molecular Therapy104 citationsDOIOpen Access PDF

Topics & Concepts

Cancer researchChimeric antigen receptorTumor microenvironmentProstate cancerImmunologyMedicineAntigenImmune systemT cellImmunotherapyCancerBiologyInternal medicineCAR-T cell therapy researchImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers
Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity | Litcius