Novel one-pot synthesis of a library of 2-aryloxy-1,4-naphthoquinone derivatives. Determination of antifungal and antibacterial activity
Katherine Chaves-Carballo, Guy Lamoureux, Alice L. Pérez, Alexandre Bella Cruz, Valdir Cechinel Filho
Abstract
The development of new antibiotics and inexpensive antifungals is an important field of research. Based on the privileged pharmacophore of lawsone, a series of phenolic ether derivatives of 1,4-naphthoquinone were synthesized easily in one step in reasonable yields.
Topics & Concepts
NaphthoquinoneLawsoneAntifungalPharmacophoreChemistryCombinatorial chemistry1,4-NaphthoquinoneEtherJugloneAntibacterial activityOrganic chemistryStereochemistryBacteriaBiologyMicrobiologyGeneticsBioactive Compounds and Antitumor AgentsMorinda citrifolia extract usesSynthesis and biological activity