Discovery and Optimization of Triazine Nitrile Inhibitors of <i>Toxoplasma gondii</i> Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS
Jeffery D. Zwicker, David W. Smith, Alfredo J. Guerra, Jacob R. Hitchens, Nicole Haug, Steve Vander Roest, Pil H. Lee, Bo Wen, Duxin Sun, Lu Wang, Richard F. Keep, Jianming Xiang, Vern B. Carruthers, Scott D. Larsen
Abstract
CPL genetic knockout.
Topics & Concepts
Toxoplasma gondiiToxoplasmosisBiologyAntiparasiticAntiparasitic agentPharmacologyVirologyImmunologyMedicinePathologyAntibodyToxoplasma gondii Research StudiesSynthesis and Characterization of Heterocyclic CompoundsHerpesvirus Infections and Treatments