Synthesis of Spirocyclic β‐ and γ‐Sultams by One‐Pot Reductive Cyclization of Cyanoalkylsulfonyl Fluorides
Kateryna O. Stepannikova, Bohdan V. Vashchenko, Oleksandr O. Grygorenko, Marian V. Gorichko, Artem Cherepakha, Yurii S. Moroz, Yulian M. Volovenko, Serhii Zhersh
Abstract
One‐pot intramolecular cyclization of novel sp 3 ‐enriched cyanoalkylsulfonyl fluorides into spirocyclic β‐ or γ‐sultams is disclosed. The method relies on nitrile group reduction followed by sulfonylation of amino group thus formed upon mild conditions (NaBH 4 , NiCl 2 · 6H 2 O in MeOH). Cyclization proceeds smoothly with considerable efficiency (48–84 %, 10 examples) on up to 30 g scale. The cyanoalkylsulfonyl fluoride intermediates can be obtained via S‐nucleophilic substitution in β‐functionalized alkanenitriles or double alkylation of α‐alkylthioacetonitrile, followed by oxidative chlorination with Cl 2 and further reaction with KHF 2 . The title mono‐ and bifunctional sultams are advanced sp 3 ‐enriched building blocks for drug discovery and organic synthesis providing novel substitution patterns and frameworks mimicking saturated nitrogen heterocycles such as pyrrolidine/pyrrolidone.