Wighteone, a prenylated flavonoid from licorice, inhibits growth of SW480 colorectal cancer cells by allosteric inhibition of Akt
Xiaofei Chen, Ruili Ma, Weiguo Wu, Ran Gao, Yikang Shu, Mingxin Dong, Mengzhe Guo, Daoquan Tang, Danhua Li, Shuai Ji
Topics & Concepts
Protein kinase BAllosteric regulationChemistryCancer researchCancer cellPI3K/AKT/mTOR pathwayApoptosisColorectal cancerPharmacologyCancerMedicineBiochemistryEnzymeInternal medicinePharmacological Effects of Natural CompoundsQuinazolinone synthesis and applicationsBerberine and alkaloids research