Immunoglobulin M bullous pemphigoid: An enigma
Rosalie Baardman, Barbara Horváth, Maria C. Bolling, Hendri H. Pas, Gilles F.H. Diercks
Abstract
Bullous pemphigoid is an autoimmune blistering disease characterized by pruritus, tense blisters and erosions of the skin or mucosae, subepidermal splitting, and linear IgG or complement deposition along the epidermal basement membrane zone (BMZ), directed against the hemidesmosomal proteins BP180 and BP230.1 Deposition of IgA in conjunction with IgG is regularly found in bullous pemphigoid, whereas deposition of only IgA along the epidermal BMZ is known as linear IgA disease.
Topics & Concepts
Bullous pemphigoidMedicinePemphigoidBlistersBasement membraneImmunoglobulin ADermatologyCicatricial pemphigoidAntibodyAutoimmune diseasePathologyImmunoglobulin GImmunologyAutoimmune Bullous Skin DiseasesCoagulation, Bradykinin, Polyphosphates, and AngioedemaUrticaria and Related Conditions